Table 3 from Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins | Semantic Scholar (2024)

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Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization.

It is demonstrated that oral supplementation with bucillamine, carvedilol, metformin, or phenformin does not affect UVR-induced carcinogenesis in hairless mice.

Results suggest that the 1% brimonidine cream probably absorbed the UVR, and therefore, a delay in tumor formation was only seen whenBrimonidine was applied before irradiation, but there can be multiple reasons for this delay in photocarcinogenesis.

Targeting PPARγ may be useful for the prevention and treatment of keratinocyte-derived skin cancer.

The potential of AFL to delay squamous cell carcinoma (SCC) formation and prevent photodamage in a preclinical UVR‐induced SCC model is investigated.

This data indicates that KCs, the most prevalent form of cancer worldwide, are rising dramatically and their incidence is rising dramatically, with an increasing trend in recent years.

NAM-PG was as effective in delaying UVR-induced tumour onset as NAM-mono, suggesting a dose-dependency of NAM's photoprotection compared to nicotinamide monotherapy.

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Oral administration of a hydrophilic extract of the fern Polypodium leucotomos modulates some of the effects of UVR and provides mechanistic clues for its efficacy as a systemic photoprotective agent with antioxidant and anti‐photo‐ageing properties.

Red raspberry extract could alleviate direct photodamage to the skin caused by UVB exposure through the ROS scavenger and protection against inflammatory responses, which may allow the development of novel strategies in protecting the skin subjected to UVB radiation.

Results indicate that vitamin E and its acetate analog can modulate the cellular response to UVB partly through their action on NF‐κB activation and are potential drugs for the protection from or the reduction of UVB‐associated epidermal damage.

Topical calcitriol may suppress the formation and progression of UV-induced non-melanoma skin cancer by enhancing the repair mechanism of UV damage.

It is suggested that carvedilol has a novel chemopreventive activity and topical carvingilol following UV exposure may be repurposed for preventing skin inflammation and cancer.

Rather than protecting against skin cancer, a diet rich in vitamin A seems to facilitate UV carcinogenesis in hairless mice.

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